Introduction positional cloning of disease genes and research of protome become very important in the post - genome period after completion of human genome project ( hgp ) . positional cloning is a new mean with the developing of hgp 前言人類基因組計劃的測序工作完成之后,已進(jìn)入后基因組學(xué)階段,疾病基因的定位克隆及其蛋白質(zhì)功能研究已成為研究的重要內(nèi)容。